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ea0016p404 | Neuroendocrinology | ECE2008

Total and cause-specific mortality in patients from the KIMS database: direct evidence for a beneficial effect of GH replacement therapy on mortality in adult GH deficient patients

Mattsson Anders , Koltowska-Haggstrom Maria , Saller Bernhard , Wilton Patrick , Gaillard Rolf

Growth hormone (GH) replacement in adults with severe GH deficiency (GHD) has well established beneficial effects on the cardiovascular risk profile. Whether this is associated with reduced mortality is still unclear. The present study addresses this question by analysing mortality data in KIMS (Pfizer international metabolic database) and is based on 9610 patients (47% females), accumulating 37882 patient-years of follow-up. There were 257 recorded deaths against 255.1 expect...

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ea0020p546 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The prevalence of diabetes mellitus in 9776 adult patients with childhood- and adult-onset growth hormone (GH) deficiency before GH replacement: a KIMS analysis

Abs Roger , Luger Anton , Wilton Patrick , Thunander Maria , Verhelst Johan , Goth Miklos , Koltowska-Haggstrom Maria , Mattsson Anders

Background: Untreated GH-deficiency (GHD) in adults has been suggested to be associated with an increased prevalence of type 2 diabetes mellitus (DM). Proposed causative factors are the tendency to overweight and the insulin resistance due to central adiposity.Patients and methods: The KIMS (Pfizer International Metabolic Database) was used to evaluate the prevalence of DM in both childhood-onset (CO; n=1977; 56% males) and in adult-onset (AO; ...

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Endocrine Abstracts

Total and cause-specific mortality in patients from the KIMS database: direct evidence for a beneficial effect of GH replacement therapy on mortality in adult GH deficient patients

The prevalence of diabetes mellitus in 9776 adult patients with childhood- and adult-onset growth hormone (GH) deficiency before GH replacement: a KIMS analysis

BiosciAbstracts